Protein phosphatase-1 inhibitor-2 promotes PP1γ positive regulation of synaptic transmission

Protein phosphatase-1 inhibitor-2 promotes PP1γ positive regulation of synaptic transmission

Inhibitor-2 (I-2) is a prototypic inhibitor of protein phosphatase-1 (PP1), a major serine-threonine phosphatase that regulates synaptic plasticity and learning and memory. Although I-2 is a potent inhibitor of PP1 in vitro, our previous work has elucidated that, in vivo, I-2 may act as a positive r...

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Bibliographic Details
Main Authors: Karl Foley, Haider Altimimi, Hailong Hou, Yu Zhang, Cody McKee, Makaía M. Papasergi-Scott, Hongtian Yang, Abigail Mayer, Nancy Ward, David M. MacLean, Angus C. Nairn, David Stellwagen, Houhui Xia
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
protein phosphatase-1
scaffolding protein
regulatory subunit
synaptic transmission
FRET-Förster resonance energy transfer
hippocampus
Online Access:https://www.frontiersin.org/articles/10.3389/fnsyn.2022.1021832/full

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https://www.frontiersin.org/articles/10.3389/fnsyn.2022.1021832/full

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