Structural Elucidation of a Protective B Cell Epitope on Outer Surface Protein C (OspC) of the Lyme Disease Spirochete, Borreliella burgdorferi

Structural Elucidation of a Protective B Cell Epitope on Outer Surface Protein C (OspC) of the Lyme Disease Spirochete, Borreliella burgdorferi

ABSTRACT Outer surface protein C (OspC) plays a pivotal role in mediating tick-to-host transmission and infectivity of the Lyme disease spirochete, Borreliella burgdorferi. OspC is a helical-rich homodimer that interacts with tick salivary proteins, as well as components of the mammalian immune syst...

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Bibliographic Details
Main Authors: Michael J. Rudolph, Simon A. Davis, H. M. Emranul Haque, David D. Weis, David J. Vance, Carol Lyn Piazza, Monir Ejemel, Lisa Cavacini, Yang Wang, M. Lamine Mbow, Robert D. Gilmore, Nicholas J. Mantis
Format: Article
Language:English
Published: American Society for Microbiology 2023-04-01
Series:mBio
Subjects:
Borreliella burgdorferi
Lyme disease
X-ray crystallography
monoclonal antibodies
spirochetes
vaccines
Online Access:https://journals.asm.org/doi/10.1128/mbio.02981-22

Internet

https://journals.asm.org/doi/10.1128/mbio.02981-22

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