Blocking and binding folate receptor alpha autoantibodies identify novel autism spectrum disorder subgroups

Blocking and binding folate receptor alpha autoantibodies identify novel autism spectrum disorder subgroups

Folate receptor α (FRα) autoantibodies (FRAAs) are prevalent in autism spectrum disorder (ASD). They disrupt the transportation of folate across the blood-brain barrier by binding to the FRα. Children with ASD with FRAAs have been reported to respond well to treatment with a form of folate known as...

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Bibliographic Details
Main Authors: Richard Eugene Frye, Leanna eDelhey, John eSlattery, Marie eTippett, Rebecca eWynne, Shannon eRose, Stephen Gregory Kahler, Sirish eBennuri, Stepan eMelnyk, Jeffrey M Sequeira, Edward eQuadros
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Neuroscience
Subjects:
Glutathione
Autism Spectrum Disorders
folinic acid
Redox metabolism
Folate receptor autoantibody
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00080/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00080/full

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