Duox activation in Drosophila Malpighian tubules stimulates intestinal epithelial renewal through a countercurrent flow
Summary: The gut must perform a dual role of protecting the host against toxins and pathogens while harboring mutualistic microbiota. Previous studies suggested that the NADPH oxidase Duox contributes to intestinal homeostasis in Drosophila by producing reactive oxygen species (ROS) in the gut that...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124724004376 |
| _version_ | 1797210054012698624 |
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| author | Zhonggeng Liu Hongyu Zhang Bruno Lemaitre Xiaoxue Li |
| author_facet | Zhonggeng Liu Hongyu Zhang Bruno Lemaitre Xiaoxue Li |
| author_sort | Zhonggeng Liu |
| collection | DOAJ |
| description | Summary: The gut must perform a dual role of protecting the host against toxins and pathogens while harboring mutualistic microbiota. Previous studies suggested that the NADPH oxidase Duox contributes to intestinal homeostasis in Drosophila by producing reactive oxygen species (ROS) in the gut that stimulate epithelial renewal. We find instead that the ROS generated by Duox in the Malpighian tubules leads to the production of Upd3, which enters the gut and stimulates stem cell proliferation. We describe in Drosophila the existence of a countercurrent flow system, which pushes tubule-derived Upd3 to the anterior part of the gut and stimulates epithelial renewal at a distance. Thus, our paper clarifies the role of Duox in gut homeostasis and describes the existence of retrograde fluid flow in the gut, collectively revealing a fascinating example of inter-organ communication. |
| first_indexed | 2024-04-24T10:04:29Z |
| format | Article |
| id | doaj.art-c097732db9294a73bad061a3b3b804f4 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-04-24T10:04:29Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-c097732db9294a73bad061a3b3b804f42024-04-13T04:21:14ZengElsevierCell Reports2211-12472024-04-01434114109Duox activation in Drosophila Malpighian tubules stimulates intestinal epithelial renewal through a countercurrent flowZhonggeng Liu0Hongyu Zhang1Bruno Lemaitre2Xiaoxue Li3Institute of Urban and Horticultural Entomology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, People’s Republic of ChinaInstitute of Urban and Horticultural Entomology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, People’s Republic of ChinaGlobal Health Institute, School of Life Science, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland; Corresponding authorInstitute of Urban and Horticultural Entomology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, People’s Republic of China; Global Health Institute, School of Life Science, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland; Corresponding authorSummary: The gut must perform a dual role of protecting the host against toxins and pathogens while harboring mutualistic microbiota. Previous studies suggested that the NADPH oxidase Duox contributes to intestinal homeostasis in Drosophila by producing reactive oxygen species (ROS) in the gut that stimulate epithelial renewal. We find instead that the ROS generated by Duox in the Malpighian tubules leads to the production of Upd3, which enters the gut and stimulates stem cell proliferation. We describe in Drosophila the existence of a countercurrent flow system, which pushes tubule-derived Upd3 to the anterior part of the gut and stimulates epithelial renewal at a distance. Thus, our paper clarifies the role of Duox in gut homeostasis and describes the existence of retrograde fluid flow in the gut, collectively revealing a fascinating example of inter-organ communication.http://www.sciencedirect.com/science/article/pii/S2211124724004376CP: Developmental biologyCP: Immunology |
| spellingShingle | Zhonggeng Liu Hongyu Zhang Bruno Lemaitre Xiaoxue Li Duox activation in Drosophila Malpighian tubules stimulates intestinal epithelial renewal through a countercurrent flow Cell Reports CP: Developmental biology CP: Immunology |
| title | Duox activation in Drosophila Malpighian tubules stimulates intestinal epithelial renewal through a countercurrent flow |
| title_full | Duox activation in Drosophila Malpighian tubules stimulates intestinal epithelial renewal through a countercurrent flow |
| title_fullStr | Duox activation in Drosophila Malpighian tubules stimulates intestinal epithelial renewal through a countercurrent flow |
| title_full_unstemmed | Duox activation in Drosophila Malpighian tubules stimulates intestinal epithelial renewal through a countercurrent flow |
| title_short | Duox activation in Drosophila Malpighian tubules stimulates intestinal epithelial renewal through a countercurrent flow |
| title_sort | duox activation in drosophila malpighian tubules stimulates intestinal epithelial renewal through a countercurrent flow |
| topic | CP: Developmental biology CP: Immunology |
| url | http://www.sciencedirect.com/science/article/pii/S2211124724004376 |
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