Deciphering Biomarkers for Leptomeningeal Metastasis in Malignant Hemopathies (Lymphoma/Leukemia) Patients by Comprehensive Multipronged Proteomics Characterization of Cerebrospinal Fluid

Deciphering Biomarkers for Leptomeningeal Metastasis in Malignant Hemopathies (Lymphoma/Leukemia) Patients by Comprehensive Multipronged Proteomics Characterization of Cerebrospinal Fluid

In the present work, leptomeningeal disease, a very destructive form of systemic cancer, was characterized from several proteomics points of view. This pathology involves the invasion of the leptomeninges by malignant tumor cells. The tumor spreads to the central nervous system through the cerebrosp...

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Bibliographic Details
Main Authors: Pablo Juanes-Velasco, Norma Galicia, Elisa Pin, Ricardo Jara-Acevedo, Javier Carabias-Sánchez, Rodrigo García-Valiente, Quentin Lecrevisse, Carlos Eduardo Pedreira, Rafael Gongora, Jose Manuel Sanchez-Santos, Héctor Lorenzo-Gil, Alicia Landeira-Viñuela, Halin Bareke, Alberto Orfao, Peter Nilsson, Manuel Fuentes
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cancers
Subjects:
cerebrospinal fluid (CSF)
leptomeningeal metastasis (LM)
biomarkers
high-abundant protein depletion
CSF-stabilizing reagents
tumor infiltrating
Online Access:https://www.mdpi.com/2072-6694/14/2/449

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https://www.mdpi.com/2072-6694/14/2/449

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