IL-17A-driven psoriasis is critically dependent on IL-36 signaling

IL-17A-driven psoriasis is critically dependent on IL-36 signaling

Plaque psoriasis is an autoinflammatory and autoimmune skin disease, affecting 1-3% of the population worldwide. Previously, high levels of IL-36 family cytokines were found in psoriatic skin lesions, thereby contributing to keratinocyte hyperproliferation and infiltration of immune cells such as ne...

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Bibliographic Details
Main Authors: Berenice Fischer, Tanja Kübelbeck, Antonia Kolb, Julia Ringen, Ari Waisman, Miriam Wittmann, Susanne Karbach, Stephan Marcus Kölsch, Daniela Kramer
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Immunology
Subjects:
anti-IL36R
psoriasis
IL-17A
keratinocytes
imiquimod
systemic inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1256133/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1256133/full

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