Co‐occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence

Co‐occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence

Uveal melanoma (UM) is the most common intraocular tumor in adults. Recurrent mutations in BRCA1‐associated protein 1 (BAP1) and splicing factor 3B subunit 1 (SF3B1) display a mutually exclusive pattern in UM, but the underlying mechanism is unknown. We show that combined BAP1 deficiency and SF3B1 h...

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Bibliographic Details
Main Authors: Le Yu, Dan Zhou, Guiming Zhang, Zhonglu Ren, Xin Luo, Peng Liu, Steven W. Plouffe, Zhipeng Meng, Toshiro Moroishi, Yilei Li, Yiyue Zhang, Joan Heller Brown, Shuwen Liu, Kun‐Liang Guan
Format: Article
Language:English
Published: Wiley 2022-02-01
Series:Molecular Oncology
Subjects:
BAP1
mutually exclusive pattern
recurrent mutations
senescence
SF3B1
uveal melanoma
Online Access:https://doi.org/10.1002/1878-0261.13128

Internet

https://doi.org/10.1002/1878-0261.13128

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