An Elusive Target: Inhibitors of JC Polyomavirus Infection and Their Development as Therapeutics for the Treatment of Progressive Multifocal Leukoencephalopathy

An Elusive Target: Inhibitors of JC Polyomavirus Infection and Their Development as Therapeutics for the Treatment of Progressive Multifocal Leukoencephalopathy

Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disease caused by infection with JC Polyomavirus (JCPyV). Despite the identification of the disease and isolation of the causative pathogen over fifty years ago, no antiviral treatments or prophylactic vaccines exist. Disease o...

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Bibliographic Details
Main Authors: Jacob Kaiserman, Bethany A. O’Hara, Sheila A. Haley, Walter J. Atwood
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
polyomavirus
antiviral
drug discovery
progressive multilocal encephalopathy
PML
signaling inhibitor
Online Access:https://www.mdpi.com/1422-0067/24/10/8580

Internet

https://www.mdpi.com/1422-0067/24/10/8580

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