Prediction for optimal dosage of pazopanib under various clinical situations using physiologically based pharmacokinetic modeling

Prediction for optimal dosage of pazopanib under various clinical situations using physiologically based pharmacokinetic modeling

This study aimed to apply a physiologically based pharmacokinetic (PBPK) model to predict optimal dosing regimens of pazopanib (PAZ) for safe and effective administration when co-administered with CYP3A4 inhibitors, acid-reducing agents, food, and administered in patients with hepatic impairment. He...

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Bibliographic Details
Main Authors: Chunnuan Wu, Bole Li, Shuai Meng, Linghui Qie, Jie Zhang, Guopeng Wang, Cong Cong Ren
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
pazopanib
PBPK model
dosing regimen adjustment
hepatic impairment model
food effect
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.963311/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.963311/full

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