TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells

TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells

TRIM28 is a corepressor that mediates transcriptional silencing by establishing local heterochromatin. Here, we show that deletion of TRIM28 in neural progenitor cells (NPCs) results in high-level expression of two groups of endogenous retroviruses (ERVs): IAP1 and MMERVK10C. We find that NPCs use T...

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Bibliographic Details
Main Authors: Liana Fasching, Adamandia Kapopoulou, Rohit Sachdeva, Rebecca Petri, Marie E. Jönsson, Christian Männe, Priscilla Turelli, Patric Jern, Florence Cammas, Didier Trono, Johan Jakobsson
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714010158

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http://www.sciencedirect.com/science/article/pii/S2211124714010158

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