Single-cell sequencing of the small and AT-skewed genome of malaria parasites

Abstract Single-cell genomics is a rapidly advancing field; however, most techniques are designed for mammalian cells. We present a single-cell sequencing pipeline for an intracellular parasite, Plasmodium falciparum, with a small genome of extreme base content. Through optimization of a quasi-linea...

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Bibliographic Details
Main Authors: Shiwei Liu, Adam C. Huckaby, Audrey C. Brown, Christopher C. Moore, Ian Burbulis, Michael J. McConnell, Jennifer L. Güler
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Genome Medicine
Subjects:
Online Access:https://doi.org/10.1186/s13073-021-00889-9