SYNTHESIS, LSD1 INHIBITORY ACTIVITY, AND LSD1 BINDING MODEL OF OPTICALLY PURE LYSINE-PCPA CONJUGATES

SYNTHESIS, LSD1 INHIBITORY ACTIVITY, AND LSD1 BINDING MODEL OF OPTICALLY PURE LYSINE-PCPA CONJUGATES

Compounds that inhibit the catalytic function of lysine-specific demethylase 1 (LSD1) are interesting as therapeutic agents. Recently, we identified three lysine-phenylcyclopropylamine conjugates, NCD18, NCD25, and NCD41, which are potent LSD1 inactivators. However, in our previous study, because we...

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Bibliographic Details
Main Authors: Yukihiro Itoh, Daisuke Ogasawara, Yosuke Ota, Tamio Mizukami, Takayoshi Suzuki
Format: Article
Language:English
Published: Elsevier 2014-02-01
Series:Computational and Structural Biotechnology Journal
Subjects:
epigenetics
histone demethylase
lysine-specific demethylase
protein-targeted drug delivery
ligand-protein interaction
drug discovery
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037014600052

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http://www.sciencedirect.com/science/article/pii/S2001037014600052

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