Synthesis of New Imidazopyridine Nucleoside Derivatives Designed as Maribavir Analogues

Synthesis of New Imidazopyridine Nucleoside Derivatives Designed as Maribavir Analogues

The strong inhibition of Human Cytomegalovirus (HCMV) replication by benzimidazole nucleosides, like Triciribine and Maribavir, has prompted us to expand the structure–activity relationships of the benzimidazole series, using as a central core the imidazo[4,5-b]pyridine scaffold. We have thus synthe...

Full description

Bibliographic Details
Main Authors: Georgios Papadakis, Maria Gerasi, Robert Snoeck, Panagiotis Marakos, Graciela Andrei, Nikolaos Lougiakis, Nicole Pouli
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Molecules
Subjects:
benzimidazole
nucleosides
imidazo[4,5-b]pyridine
HCMV
antiviral activity
antiproliferative activity
Online Access:https://www.mdpi.com/1420-3049/25/19/4531

Internet

https://www.mdpi.com/1420-3049/25/19/4531

Similar Items