Mechanisms of Mitochondrial Dysfunction in Lysosomal Storage Disorders: A Review

Mechanisms of Mitochondrial Dysfunction in Lysosomal Storage Disorders: A Review

Mitochondrial dysfunction is emerging as an important contributory factor to the pathophysiology of lysosomal storage disorders (LSDs). The cause of mitochondrial dysfunction in LSDs appears to be multifactorial, although impaired mitophagy and oxidative stress appear to be common inhibitory mechani...

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Bibliographic Details
Main Authors: Karolina M. Stepien, Federico Roncaroli, Nadia Turton, Christian J. Hendriksz, Mark Roberts, Robert A. Heaton, Iain Hargreaves
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Journal of Clinical Medicine
Subjects:
mitochondrial dysfunction
lysosomal storage diseases
oxidative stress
inflammation
reactive oxygen species
autophagy
Online Access:https://www.mdpi.com/2077-0383/9/8/2596

Internet

https://www.mdpi.com/2077-0383/9/8/2596

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