Induction of tolerogenic dendritic cells by activated TGF-β/Akt/Smad2 signaling in RIG-I-deficient stemness-high human liver cancer cells

Induction of tolerogenic dendritic cells by activated TGF-β/Akt/Smad2 signaling in RIG-I-deficient stemness-high human liver cancer cells

Abstract Background Dendritic cells (DCs) alter their role from being immunostimulatory to immunosuppressive at advanced stages of tumor progression, but the influence of cancer stem cells (CSCs) and their secreted factors on generation and phenotypic change of DCs is unknown. Retinoic acid-inducibl...

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Bibliographic Details
Main Authors: Ming Zhong, Cheng Zhong, Wen Cui, Guanghui Wang, Gongpu Zheng, Li Li, Jing Zhang, Rujing Ren, Huijei Gao, Tingting Wang, Xin Li, Jiantu Che, Eiichi Gohda
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Cancer
Subjects:
Tumor-infiltrating dendritic cell
Immune tolerance
Mixed lymphocyte reaction
Tumor microenvironment
Hepatocellular carcinoma
Online Access:http://link.springer.com/article/10.1186/s12885-019-5670-9

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http://link.springer.com/article/10.1186/s12885-019-5670-9

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