Functional Recovery of Human Cells Harbouring the Mitochondrial DNA Mutation MERRF A8344G via Peptide-Mediated Mitochondrial Delivery

Functional Recovery of Human Cells Harbouring the Mitochondrial DNA Mutation MERRF A8344G via Peptide-Mediated Mitochondrial Delivery

We explored the feasibility of mitochondrial therapy using the cell-penetrating peptide Pep-1 to transfer mitochondrial DNA (mtDNA) between cells and rescue a cybrid cell model of the mitochondrial disease myoclonic epilepsy with ragged-red fibres (MERRF) syndrome. Pep-1-conjugated wild-type mitocho...

Full description

Bibliographic Details
Main Authors: Jui-Chih Chang, Ko-Hung Liu, Yu-Chi Li, Shou-Jen Kou, Yau-Huei Wei, Chieh-Sen Chuang, Mingli Hsieh, Chin-San Liu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2012-09-01
Series:Neurosignals
Subjects:
Mitochondrial biogenesis
Mitochondrial fusion/fission proteins
Mitochondrial delivery
Myoclonic epilepsy with ragged-red fibres syndrome
Mitochondrial functions
Cell-penetrating peptide
Online Access:http://www.karger.com/Article/FullText/341981

Internet

http://www.karger.com/Article/FullText/341981

Similar Items