Dietary advanced glycation end-product consumption leads to mechanical stiffening of murine intervertebral discs

Dietary advanced glycation end-product consumption leads to mechanical stiffening of murine intervertebral discs

Back pain is a leading cause of disability and is strongly associated with intervertebral disc (IVD) degeneration. Reducing structural disruption and catabolism in IVD degeneration remains an important clinical challenge. Pro-oxidant and structure-modifying advanced glycation end-products (AGEs) con...

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Bibliographic Details
Main Authors: Divya Krishnamoorthy, Robert C. Hoy, Devorah M. Natelson, Olivia M. Torre, Damien M. Laudier, James C. Iatridis, Svenja Illien-Jünger
Format: Article
Language:English
Published: The Company of Biologists 2018-12-01
Series:Disease Models & Mechanisms
Subjects:
Spine
Intervertebral disc degeneration
Diabetes
Advanced glycation end-products
Diet
Online Access:http://dmm.biologists.org/content/11/12/dmm036012

Internet

http://dmm.biologists.org/content/11/12/dmm036012

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