Discerning asthma endotypes through comorbidity mapping

Asthma is a heterogeneous, complex syndrome that arises in individuals with various genetic and exposure variations. Here, the authors show that disease comorbidity patterns can serve as a surrogate for these variations, and identify asthma endotypes distinguished by comorbidity patterns, asthma ris...

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Bibliographic Details
Main Authors: Gengjie Jia, Xue Zhong, Hae Kyung Im, Nathan Schoettler, Milton Pividori, D. Kyle Hogarth, Anne I. Sperling, Steven R. White, Edward T. Naureckas, Christopher S. Lyttle, Chikashi Terao, Yoichiro Kamatani, Masato Akiyama, Koichi Matsuda, Michiaki Kubo, Nancy J. Cox, Carole Ober, Andrey Rzhetsky, Julian Solway
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33628-8