Toxicity Study and Binding Analysis of Newly Synthesized Antifungal <i>N</i>-(4-aryl/cyclohexyl)-2-(pyridine-4-yl carbonyl) hydrazinecarbothioamide Derivative with Bovine Serum Albumin

Toxicity Study and Binding Analysis of Newly Synthesized Antifungal <i>N</i>-(4-aryl/cyclohexyl)-2-(pyridine-4-yl carbonyl) hydrazinecarbothioamide Derivative with Bovine Serum Albumin

The presence of the p-aryl/cyclohexyl ring in the <i>N</i>-(4-aryl/cyclohexyl)-2-(pyridine-4-yl carbonyl) hydrazine carbothioamide derivative (2C) is reported to enhance the antifungal properties when compared to those of itraconazole. Serum albumins present in plasma bind and transport...

Full description

Bibliographic Details
Main Authors: Tanveer A. Wani, Ahmed H. Bakheit, Seema Zargar, Nojood Altwaijry, Mashooq Ahmad Bhat, Hamad M. Alkahtani, Lamees S. Al-Rasheed
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
BSA–ligand interaction
quenching mechanism
molecular docking
cytotoxicity
FRET
fluorescence
Online Access:https://www.mdpi.com/1422-0067/24/5/4942

Internet

https://www.mdpi.com/1422-0067/24/5/4942

Similar Items