RND-type Drug Efflux Pumps from Gram-negative bacteria: Molecular Mechanism and Inhibition

RND-type Drug Efflux Pumps from Gram-negative bacteria: Molecular Mechanism and Inhibition

Drug efflux protein complexes confer multidrug resistance on bacteria by transporting a wide spectrum of structurally diverse antibiotics. Moreover, organisms can only acquire resistance in the presence of an active efflux pump. The substrate range of drug efflux pumps is not limited to antibiotics...

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Bibliographic Details
Main Authors: Henrietta eVenter, Rumana eMowla, Thelma eOhene-Agyei, Shutao eMa
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Microbiology
Subjects:
Gram-Negative Bacteria
Virulence
Biofilm
pathogen
multidrug resistance
drug efflux system
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00377/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00377/full

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