Excessive Activation of Notch Signaling in Macrophages Promote Kidney Inflammation, Fibrosis, and Necroptosis

Excessive Activation of Notch Signaling in Macrophages Promote Kidney Inflammation, Fibrosis, and Necroptosis

Diabetic nephropathy (DN) is one of the main causes of end-stage renal disease (ESRD). Existing treatments cannot control the progression of diabetic nephropathy very well. In diabetic nephropathy, Many monocytes and macrophages infiltrate kidney tissue. However, the role of these cells in the patho...

Full description

Bibliographic Details
Main Authors: Tiankui Ma, Xin Li, Yonghong Zhu, Shufan Yu, Tianyan Liu, Xiaodan Zhang, Dong Chen, Shuyan Du, Tong Chen, Shuo Chen, Yanyan Xu, Qiuling Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Immunology
Subjects:
diabetic kidney disease
macrophages
kidney inflammation
renal fibrosis
necroptosis
diabetic nephropathy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.835879/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.835879/full

Similar Items