Highly Selective MIF Ketonase Inhibitor KRP-6 Diminishes M1 Macrophage Polarization and Metabolic Reprogramming

Highly Selective MIF Ketonase Inhibitor KRP-6 Diminishes M1 Macrophage Polarization and Metabolic Reprogramming

Macrophage polarization is highly involved in autoimmunity. M1 polarized macrophages drive inflammation and undergo metabolic reprogramming, involving downregulation of mitochondrial energy production and acceleration of glycolysis. Macrophage migration inhibitory factor (MIF), an enigmatic tautomer...

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Bibliographic Details
Main Authors: Eszter Vámos, Nikoletta Kálmán, Eva Maria Sturm, Barsha Baisakhi Nayak, Julia Teppan, Viola Bagóné Vántus, Dominika Kovács, Lilla Makszin, Tamás Loránd, Ferenc Gallyas, Balázs Radnai
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Antioxidants
Subjects:
macrophage polarization
metabolic reprogramming
glycolysis
oxidative phosphorylation
MIF
MIF inhibitor
Online Access:https://www.mdpi.com/2076-3921/12/10/1790

Internet

https://www.mdpi.com/2076-3921/12/10/1790

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