Correlating physicochemical and biological properties to define critical quality attributes of a rAAV vaccine candidate

Correlating physicochemical and biological properties to define critical quality attributes of a rAAV vaccine candidate

Recombinant adeno-associated viruses (rAAVs) are a preferred vector system in clinical gene transfer. A fundamental challenge to formulate and deliver rAAVs as stable and efficacious vaccines is to elucidate interrelationships between the vector’s physicochemical properties and biological potency. T...

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Bibliographic Details
Main Authors: Prashant Kumar, Michael Wang, Ozan S. Kumru, John M. Hickey, Julio Sanmiguel, Nerea Zabaleta, Luk H. Vandenberghe, Sangeeta B. Joshi, David B. Volkin
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
adeno-associated virus
analytical characterization
transduction efficiency
immunogenicity
formulation
stability
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050123000943

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http://www.sciencedirect.com/science/article/pii/S2329050123000943

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