Nampt activator P7C3 ameliorates diabetes and improves skeletal muscle function modulating cell metabolism and lipid mediators

Nampt activator P7C3 ameliorates diabetes and improves skeletal muscle function modulating cell metabolism and lipid mediators

Abstract Background Nicotinamide phosphoribosyltransferase (Nampt), a key enzyme in NAD salvage pathway is decreased in metabolic diseases, and its precise role in skeletal muscle function is not known. We tested the hypothesis, Nampt activation by P7C3 (3,6‐dibromo‐α‐[(phenylamino)methyl]‐9H‐carbaz...

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Bibliographic Details
Main Authors: Ravikumar Manickam, Jared Tur, Sachin L. Badole, Kalyan C. Chapalamadugu, Puja Sinha, Zhiying Wang, David W. Russ, Marco Brotto, Srinivas M. Tipparaju
Format: Article
Language:English
Published: Wiley 2022-04-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
P7C3
Nampt
Skeletal muscle
Insulin sensitivity
Physical performance
Pathophysiology
Online Access:https://doi.org/10.1002/jcsm.12887

Internet

https://doi.org/10.1002/jcsm.12887

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