G protein-coupled estrogen receptor 1 regulates renal endothelin-1 signaling system in a sex-specific manner

G protein-coupled estrogen receptor 1 regulates renal endothelin-1 signaling system in a sex-specific manner

Demographic studies reveal lower prevalence of hypertension among premenopausal females compared to age-matched males. The kidney plays a central role in the maintenance of sodium (Na+) homeostasis and consequently blood pressure. Renal endothelin-1 (ET-1) is a pro-natriuretic peptide that contribut...

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Bibliographic Details
Main Authors: Ginger L. Guthrie, Rawan N. Almutlaq, Sho Sugahara, Maryam K. Butt, Craig R. Brooks, David M. Pollock, Eman Y. Gohar
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Physiology
Subjects:
GPR30
sex differences
kidney medulla
sodium handling
blood pressure
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1086973/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2023.1086973/full

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