Exploiting inter-tissue stress signaling mechanisms to preserve organismal proteostasis during aging
Aging results in a decline of cellular proteostasis capacity which culminates in the accumulation of phototoxic material, causing the onset of age-related maladies and ultimately cell death. Mechanisms that regulate proteostasis such as cellular stress response pathways sense disturbances in the pro...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-07-01
|
| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1228490/full |
| _version_ | 1827908744703377408 |
|---|---|
| author | Patricija van Oosten-Hawle |
| author_facet | Patricija van Oosten-Hawle |
| author_sort | Patricija van Oosten-Hawle |
| collection | DOAJ |
| description | Aging results in a decline of cellular proteostasis capacity which culminates in the accumulation of phototoxic material, causing the onset of age-related maladies and ultimately cell death. Mechanisms that regulate proteostasis such as cellular stress response pathways sense disturbances in the proteome. They are activated to increase the expression of protein quality control components that counteract cellular damage. Utilizing invertebrate model organisms such as Caenorhabditis elegans, it has become increasingly evident that the regulation of proteostasis and the activation of cellular stress responses is not a cell autonomous process. In animals, stress responses are orchestrated by signals coming from other tissues, including the nervous system, the intestine and the germline that have a profound impact on determining the aging process. Genetic pathways discovered in C. elegans that facilitate cell nonautonomous regulation of stress responses are providing an exciting feeding ground for new interventions. In this review I will discuss cell nonautonomous proteostasis mechanisms and their impact on aging as well as ongoing research and clinical trials that can increase organismal proteostasis to lengthen health- and lifespan. |
| first_indexed | 2024-03-13T01:27:29Z |
| format | Article |
| id | doaj.art-c0d45f07f7c94aa3bba8e903bf0b7506 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-03-13T01:27:29Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-c0d45f07f7c94aa3bba8e903bf0b75062023-07-04T13:38:35ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-07-011410.3389/fphys.2023.12284901228490Exploiting inter-tissue stress signaling mechanisms to preserve organismal proteostasis during agingPatricija van Oosten-HawleAging results in a decline of cellular proteostasis capacity which culminates in the accumulation of phototoxic material, causing the onset of age-related maladies and ultimately cell death. Mechanisms that regulate proteostasis such as cellular stress response pathways sense disturbances in the proteome. They are activated to increase the expression of protein quality control components that counteract cellular damage. Utilizing invertebrate model organisms such as Caenorhabditis elegans, it has become increasingly evident that the regulation of proteostasis and the activation of cellular stress responses is not a cell autonomous process. In animals, stress responses are orchestrated by signals coming from other tissues, including the nervous system, the intestine and the germline that have a profound impact on determining the aging process. Genetic pathways discovered in C. elegans that facilitate cell nonautonomous regulation of stress responses are providing an exciting feeding ground for new interventions. In this review I will discuss cell nonautonomous proteostasis mechanisms and their impact on aging as well as ongoing research and clinical trials that can increase organismal proteostasis to lengthen health- and lifespan.https://www.frontiersin.org/articles/10.3389/fphys.2023.1228490/fullproteostasisagingstress responsestranscellularhealthspan |
| spellingShingle | Patricija van Oosten-Hawle Exploiting inter-tissue stress signaling mechanisms to preserve organismal proteostasis during aging Frontiers in Physiology proteostasis aging stress responses transcellular healthspan |
| title | Exploiting inter-tissue stress signaling mechanisms to preserve organismal proteostasis during aging |
| title_full | Exploiting inter-tissue stress signaling mechanisms to preserve organismal proteostasis during aging |
| title_fullStr | Exploiting inter-tissue stress signaling mechanisms to preserve organismal proteostasis during aging |
| title_full_unstemmed | Exploiting inter-tissue stress signaling mechanisms to preserve organismal proteostasis during aging |
| title_short | Exploiting inter-tissue stress signaling mechanisms to preserve organismal proteostasis during aging |
| title_sort | exploiting inter tissue stress signaling mechanisms to preserve organismal proteostasis during aging |
| topic | proteostasis aging stress responses transcellular healthspan |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1228490/full |
| work_keys_str_mv | AT patricijavanoostenhawle exploitingintertissuestresssignalingmechanismstopreserveorganismalproteostasisduringaging |