Exploiting inter-tissue stress signaling mechanisms to preserve organismal proteostasis during aging

Exploiting inter-tissue stress signaling mechanisms to preserve organismal proteostasis during aging

Aging results in a decline of cellular proteostasis capacity which culminates in the accumulation of phototoxic material, causing the onset of age-related maladies and ultimately cell death. Mechanisms that regulate proteostasis such as cellular stress response pathways sense disturbances in the pro...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Patricija van Oosten-Hawle
Fformat:	Erthygl
Iaith:	English
Cyhoeddwyd:	Frontiers Media S.A. 2023-07-01
Cyfres:	Frontiers in Physiology
Pynciau:	proteostasis aging stress responses transcellular healthspan
Mynediad Ar-lein:	https://www.frontiersin.org/articles/10.3389/fphys.2023.1228490/full

Eitemau Tebyg

Cell Non-autonomous Proteostasis Regulation in Aging and Disease
gan: Joao Vasco Ferreira, et al.
Cyhoeddwyd: (2022-06-01)

The Intestine as a Lifespan- and Proteostasis-Promoting Signaling Tissue
gan: Francesca Hodge, et al.
Cyhoeddwyd: (2022-06-01)

Proteostasis Collapse, Inter-tissue Communication and the Regulation of Aging at the Organismal Level
gan: Ehud eCohen, et al.
Cyhoeddwyd: (2015-03-01)

Organismal Roles of Hsp90
gan: Patricija van Oosten-Hawle
Cyhoeddwyd: (2023-01-01)

Mediation of organismal aging and somatic proteostasis by the germline
gan: Amirabbas eKhodakarami, et al.
Cyhoeddwyd: (2015-01-01)

Hsp90: From Cellular to Organismal Proteostasis
gan: Milán Somogyvári, et al.
Cyhoeddwyd: (2022-08-01)

Neuronal CBP-1 is Required for Enhanced Body Muscle Proteostasis in Response to Reduced Translation Downstream of mTOR
gan: Santina Snow, et al.
Cyhoeddwyd: (2024-07-01)

Targeting the Mitochondria-Proteostasis Axis to Delay Aging
gan: Andreas Zimmermann, et al.
Cyhoeddwyd: (2021-03-01)

The insulin/IGF signaling cascade modulates SUMOylation to regulate aging and proteostasis in Caenorhabditis elegans
gan: Lorna Moll, et al.
Cyhoeddwyd: (2018-11-01)

Editorial: The regulation of proteostasis in aging
gan: Ji-Xin Tang, et al.
Cyhoeddwyd: (2023-05-01)

Rates of protein synthesis are maintained in brain but reduced in skeletal muscle during dietary sulfur amino acid restriction
gan: Wenceslao Martinez, et al.
Cyhoeddwyd: (2022-08-01)

A PQM-1-Mediated Response Triggers Transcellular Chaperone Signaling and Regulates Organismal Proteostasis
gan: Daniel O’Brien, et al.
Cyhoeddwyd: (2018-06-01)

Automated, high-dimensional evaluation of physiological aging and resilience in outbred mice
gan: Zhenghao Chen, et al.
Cyhoeddwyd: (2022-04-01)

Plasma proteomic biomarker signature of age predicts health and life span
gan: Toshiko Tanaka, et al.
Cyhoeddwyd: (2020-11-01)

MicroRNAs in Age-Related Proteostasis and Stress Responses
gan: Latika Matai, et al.
Cyhoeddwyd: (2023-04-01)

Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria
gan: Ceereena Ubaida-Mohien, et al.
Cyhoeddwyd: (2019-10-01)

Protein intake and loss of proteostasis in the eldery
gan: A. N. Kirana, et al.
Cyhoeddwyd: (2021-02-01)

The Inherent Human Aging Process and the Facilitating Role of Exercise
gan: Norman R. Lazarus, et al.
Cyhoeddwyd: (2018-10-01)

Telomerase gene therapy: a novel approach to combat aging
gan: Virginia Boccardi, et al.
Cyhoeddwyd: (2012-05-01)

Neuropeptide signaling and SKN-1 orchestrate differential responses of the proteostasis network to dissimilar proteotoxic insults
gan: Hana Boocholez, et al.
Cyhoeddwyd: (2022-02-01)

Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1
gan: David F Moreno, et al.
Cyhoeddwyd: (2019-09-01)

Proteostasis Decline and Redox Imbalance in Age-Related Diseases: The Therapeutic Potential of NRF2
gan: Brigitta Buttari, et al.
Cyhoeddwyd: (2025-01-01)

Germline burden of rare damaging variants negatively affects human healthspan and lifespan
gan: Anastasia V Shindyapina, et al.
Cyhoeddwyd: (2020-04-01)

Searching for the genetic key to a long and healthy life
gan: Joris Deelen
Cyhoeddwyd: (2020-04-01)

Development of aging research in Caenorhabditis elegans: From molecular insights to therapeutic application for healthy aging
gan: Junhyo Cho, et al.
Cyhoeddwyd: (2024-01-01)

Adiponectin preserves metabolic fitness during aging
gan: Na Li, et al.
Cyhoeddwyd: (2021-04-01)

Understanding human aging and the fundamental cell signaling link in age-related diseases: the middle-aging hypovascularity hypoxia hypothesis
gan: Teow J. Phua
Cyhoeddwyd: (2023-06-01)

Hallmarks of aging: middle-aging hypovascularity, tissue perfusion and nitric oxide perspective on healthspan
gan: Teow J. Phua
Cyhoeddwyd: (2025-01-01)

Editorial: Exercise as a Countermeasure to Human Aging
gan: Bradley T. Elliott, et al.
Cyhoeddwyd: (2020-07-01)

Molecular Perspectives of Mitochondrial Adaptations and Their Role in Cardiac Proteostasis
gan: Shafiul Alam, et al.
Cyhoeddwyd: (2020-08-01)

Distinct, common and synergistic effects of insulin and IGF-1 receptors on healthy murine ageing
gan: Andrew MN Walker, et al.
Cyhoeddwyd: (2024-08-01)

Hacking Aging: A Strategy to Use Big Data From Medical Studies to Extend Human Life
gan: Peter O. Fedichev, et al.
Cyhoeddwyd: (2018-10-01)

The Autophagy-Lysosomal Pathways and Their Emerging Roles in Modulating Proteostasis in Tumors
gan: Zhen Dong, et al.
Cyhoeddwyd: (2018-12-01)

Healthy, Active Aging for People and Dogs
gan: Sandra McCune, et al.
Cyhoeddwyd: (2021-06-01)

Proteostasis During Cerebral Ischemia
gan: Audrey M. Thiebaut, et al.
Cyhoeddwyd: (2019-06-01)

Age-dependent aggregation of ribosomal RNA-binding proteins links deterioration in chromatin stability with challenges to proteostasis
gan: Julie Paxman, et al.
Cyhoeddwyd: (2022-10-01)

Novel Modulators of Proteostasis: RNAi Screen of Chromosome I in a Heat Stress Paradigm in C. elegans
gan: Andreas Kern, et al.
Cyhoeddwyd: (2018-05-01)

Disruption of Proteostasis by Natural Products and Synthetic Compounds That Induce Pervasive Unfolding of Proteins: Therapeutic Implications
gan: Nuria Vilaboa, et al.
Cyhoeddwyd: (2023-04-01)

Exploring juventology: unlocking the secrets of youthspan and longevity programs
gan: Sebastian Brandhorst, et al.
Cyhoeddwyd: (2024-04-01)

Maximizing Longevity and Healthspan: Multiple Approaches All Converging on Autophagy
gan: Akshay Bareja, et al.
Cyhoeddwyd: (2019-09-01)