Pembrolizumab for the treatment of progressive multifocal leukoencephalopathy following anti‐CD19 CAR‐T therapy: a case report

Pembrolizumab for the treatment of progressive multifocal leukoencephalopathy following anti‐CD19 CAR‐T therapy: a case report

Abstract Progressive multifocal leukoencephalopathy (PML) is an opportunistic brain infection with few treatment options and poor survival when reversal of the underlying immune dysfunction is not achievable. JC polyomavirus reactivation resulting in PML can rarely complicate chimeric antigen recept...

Full description

Bibliographic Details
Main Authors: Strachan Mackenzie, Manar Shafat, Harriet Roddy, Harpreet Hyare, Lorna Neill, Maria A. V. Marzolini, Michael Gilhooley, Teresa Marafioti, Eleanna Kara, Emilie Sanchez, Jeremy Rees, David S. Lynch, Kirsty Thomson, Kirit M. Ardeshna, Arian Laurence, Karl S. Peggs, Maeve O'Reilly, Claire Roddie
Format: Article
Language:English
Published: Wiley 2021-11-01
Series:eJHaem
Subjects:
checkpoint inhibition
chimeric antigen receptor T‐ cell
herald lesion
immune reconstitution inflammatory syndrome
pembrolizumab
progressive multifocal leukoencephalopathy
Online Access:https://doi.org/10.1002/jha2.274

Internet

https://doi.org/10.1002/jha2.274

Similar Items