PD-1 Primarily Targets TCR Signal in the Inhibition of Functional T Cell Activation

PD-1 Primarily Targets TCR Signal in the Inhibition of Functional T Cell Activation

Cancer-immunotherapy targeting programmed cell death 1 (PD-1) activates tumor-specific T cells and provides clinical benefits in various cancers. However, the molecular basis of PD-1 function is still enigmatic. Especially, it is unclear which signaling pathway PD-1 primarily targets. Besides, the c...

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Bibliographic Details
Main Authors: Reina Mizuno, Daisuke Sugiura, Kenji Shimizu, Takumi Maruhashi, Mizuki Watada, Il-mi Okazaki, Taku Okazaki
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
T cell receptor
co-receptor
PD-1
CD28
ICOS
cytokine production
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00630/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00630/full

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