Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis.

Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis.

Identification of new drug targets is vital for the advancement of drug discovery against Mycobacterium tuberculosis, especially given the increase of resistance worldwide to first- and second-line drugs. Because traditional target-based screening has largely proven unsuccessful for antibiotic disco...

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Bibliographic Details
Main Authors: Thomas R Ioerger, Theresa O'Malley, Reiling Liao, Kristine M Guinn, Mark J Hickey, Nilofar Mohaideen, Kenan C Murphy, Helena I M Boshoff, Valerie Mizrahi, Eric J Rubin, Christopher M Sassetti, Clifton E Barry, David R Sherman, Tanya Parish, James C Sacchettini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3781026?pdf=render

Internet

http://europepmc.org/articles/PMC3781026?pdf=render

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