Dysregulation of cardiac mitochondrial aldehyde dehydrogenase 2: Studies in dogs with chronic heart failure

Dysregulation of cardiac mitochondrial aldehyde dehydrogenase 2: Studies in dogs with chronic heart failure

Mitochondrial (MITO) dysfunction occurs in the failing heart and contributes to worsening of heart failure (HF). Reduced aldehyde dehydrogenase 2 (ALDH2) in left ventricular (LV) myocardium of diabetic hearts has been implicated in MITO dysfunction through accumulation of toxic aldehydes including a...

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Bibliographic Details
Main Authors: Ramesh C. Gupta, Vinita Singh-Gupta, Kristina J. Szekely, Kefei Zhang, David E. Lanfear, Hani N. Sabbah
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Journal of Molecular and Cellular Cardiology Plus
Subjects:
Heart failure, aldehydes
Aldehyde dehydrogenase
Mitochondria
Protein kinase
Online Access:http://www.sciencedirect.com/science/article/pii/S2772976124000072

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http://www.sciencedirect.com/science/article/pii/S2772976124000072

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