Controlled tumor heterogeneity in a co-culture system by 3D bio-printed tumor-on-chip model

Abstract Cancer treatment resistance is a caused by presence of various types of cells and heterogeneity within the tumor. Tumor cell–cell and cell-microenvironment interactions play a significant role in the tumor progression and invasion, which have important implications for diagnosis, and resist...

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Bibliographic Details
Main Authors: Nafiseh Moghimi, Seied Ali Hosseini, Altay Burak Dalan, Dorsa Mohammadrezaei, Aaron Goldman, Mohammad Kohandel
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-40680-x