Carbonic anhydrase 2 (CAII) supports tumor blood endothelial cell survival under lactic acidosis in the tumor microenvironment

Carbonic anhydrase 2 (CAII) supports tumor blood endothelial cell survival under lactic acidosis in the tumor microenvironment

Abstract Background Tumor endothelial cells (TECs) perform tumor angiogenesis, which is essential for tumor growth and metastasis. Tumor cells produce large amounts of lactic acid from glycolysis; however, the mechanism underlying the survival of TECs to enable tumor angiogenesis under high lactic a...

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Bibliographic Details
Main Authors: Dorcas A. Annan, Nako Maishi, Tomoyoshi Soga, Randa Dawood, Cong Li, Hiroshi Kikuchi, Takayuki Hojo, Masahiro Morimoto, Tetsuya Kitamura, Mohammad Towfik Alam, Kazuyuki Minowa, Nobuo Shinohara, Jin-Min Nam, Yasuhiro Hida, Kyoko Hida
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Cell Communication and Signaling
Subjects:
Lactic acidosis
Tumor endothelial cells
Carbonic anhydrase 2 (CAII)
pH regulation
Angiogenesis
Online Access:https://doi.org/10.1186/s12964-019-0478-4

Internet

https://doi.org/10.1186/s12964-019-0478-4

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