Relationship between vacA Types and Development of Gastroduodenal Diseases
The Helicobacter pylori vacuolating cytotoxin (VacA) is a secreted pore-forming toxin and a major virulence factor in the pathogenesis of H. pylori infection. While VacA is present in almost all strains, only some forms are toxigenic and pathogenic. While vacA and its genotypes are considered as mar...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-06-01
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| Series: | Toxins |
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| Online Access: | http://www.mdpi.com/2072-6651/8/6/182 |
| _version_ | 1811184792462426112 |
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| author | Tran Thi Huyen Trang Tran Thanh Binh Yoshio Yamaoka |
| author_facet | Tran Thi Huyen Trang Tran Thanh Binh Yoshio Yamaoka |
| author_sort | Tran Thi Huyen Trang |
| collection | DOAJ |
| description | The Helicobacter pylori vacuolating cytotoxin (VacA) is a secreted pore-forming toxin and a major virulence factor in the pathogenesis of H. pylori infection. While VacA is present in almost all strains, only some forms are toxigenic and pathogenic. While vacA and its genotypes are considered as markers of H. pylori-related diseases or disorders, the pathophysiological mechanisms of VacA and its genotypes remain controversial. This review outlines key findings of publications regarding vacA with emphasis on the relationship between vacA genotypes and the development of human disease. |
| first_indexed | 2024-04-11T13:18:27Z |
| format | Article |
| id | doaj.art-c0e315b397c24371ad0a2d0a46d6e503 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-11T13:18:27Z |
| publishDate | 2016-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-c0e315b397c24371ad0a2d0a46d6e5032022-12-22T04:22:18ZengMDPI AGToxins2072-66512016-06-018618210.3390/toxins8060182toxins8060182Relationship between vacA Types and Development of Gastroduodenal DiseasesTran Thi Huyen Trang0Tran Thanh Binh1Yoshio Yamaoka2Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-Machi, Yufu-City, Oita 879-5593, JapanDepartment of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-Machi, Yufu-City, Oita 879-5593, JapanDepartment of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-Machi, Yufu-City, Oita 879-5593, JapanThe Helicobacter pylori vacuolating cytotoxin (VacA) is a secreted pore-forming toxin and a major virulence factor in the pathogenesis of H. pylori infection. While VacA is present in almost all strains, only some forms are toxigenic and pathogenic. While vacA and its genotypes are considered as markers of H. pylori-related diseases or disorders, the pathophysiological mechanisms of VacA and its genotypes remain controversial. This review outlines key findings of publications regarding vacA with emphasis on the relationship between vacA genotypes and the development of human disease.http://www.mdpi.com/2072-6651/8/6/182VacA genotypesvacuolationprolonged Helicobacter pylori infectionH. pylori-mediated diseases |
| spellingShingle | Tran Thi Huyen Trang Tran Thanh Binh Yoshio Yamaoka Relationship between vacA Types and Development of Gastroduodenal Diseases Toxins VacA genotypes vacuolation prolonged Helicobacter pylori infection H. pylori-mediated diseases |
| title | Relationship between vacA Types and Development of Gastroduodenal Diseases |
| title_full | Relationship between vacA Types and Development of Gastroduodenal Diseases |
| title_fullStr | Relationship between vacA Types and Development of Gastroduodenal Diseases |
| title_full_unstemmed | Relationship between vacA Types and Development of Gastroduodenal Diseases |
| title_short | Relationship between vacA Types and Development of Gastroduodenal Diseases |
| title_sort | relationship between vaca types and development of gastroduodenal diseases |
| topic | VacA genotypes vacuolation prolonged Helicobacter pylori infection H. pylori-mediated diseases |
| url | http://www.mdpi.com/2072-6651/8/6/182 |
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