Genetic Disruption of KLF1 K74 SUMOylation in Hematopoietic System Promotes Healthy Longevity in Mice

Genetic Disruption of KLF1 K74 SUMOylation in Hematopoietic System Promotes Healthy Longevity in Mice

Abstract The quest for rejuvenation and prolonged lifespan through transfusion of young blood has been studied for decades with the hope of unlocking the mystery of the key substance(s) that exists in the circulating blood of juvenile organisms. However, a pivotal mediator has yet been identified. H...

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Bibliographic Details
Main Authors: Yu‐Chiau Shyu, Po‐Cheng Liao, Ting‐Shou Huang, Chun‐Ju Yang, Mu‐Jie Lu, Shih‐Ming Huang, Xin‐Yu Lin, Cai‐Cin Liou, Yu‐Hsiang Kao, Chi‐Huan Lu, Hui‐Ling Peng, Jim‐Ray Chen, Wen‐Jin Cherng, Ning‐I Yang, Yung‐Chang Chen, Heng‐Chih Pan, Si‐Tse Jiang, Chih‐Chin Hsu, Gigin Lin, Shin‐Sheng Yuan, Paul Wei‐Che Hsu, Kou‐Juey Wu, Tung‐Liang Lee, Che‐Kun James Shen
Format: Article
Language:English
Published: Wiley 2022-09-01
Series:Advanced Science
Subjects:
aging
antiaging
hematopoietic stem cells (HSCs)
KLF1/EKLF
SUMOylation
Online Access:https://doi.org/10.1002/advs.202201409

Internet

https://doi.org/10.1002/advs.202201409

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