Novel Insights on the Role of Epigenetics in Androgen Receptor’s Expression in Prostate Cancer

Novel Insights on the Role of Epigenetics in Androgen Receptor’s Expression in Prostate Cancer

The androgens/androgen receptor (AR) axis is the main therapeutic target in prostate cancer (PCa). However, while initially responsive, a subset of tumors loses AR expression through mechanisms putatively associated with epigenetic modifications. In this study, we assessed the link between the prese...

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Bibliographic Details
Main Authors: Vânia Camilo, Mariana Brütt Pacheco, Filipa Moreira-Silva, Gonçalo Outeiro-Pinho, Vítor M. Gaspar, João F. Mano, C. Joana Marques, Rui Henrique, Carmen Jerónimo
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Biomolecules
Subjects:
prostate cancer
androgen receptor
DNA methylation
epigenetics
transcriptional repression
Online Access:https://www.mdpi.com/2218-273X/13/10/1526

Internet

https://www.mdpi.com/2218-273X/13/10/1526

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