Role of KCC2-dependent potassium efflux in 4-Aminopyridine-induced Epileptiform synchronization

Role of KCC2-dependent potassium efflux in 4-Aminopyridine-induced Epileptiform synchronization

A balance between excitation and inhibition is necessary to maintain stable brain network dynamics. Traditionally, seizure activity is believed to arise from the breakdown of this delicate balance in favor of excitation with loss of inhibition. Surprisingly, recent experimental evidence suggests tha...

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Bibliographic Details
Main Authors: Oscar C. González, Zahra Shiri, Giri P. Krishnan, Timothy L. Myers, Sylvain Williams, Massimo Avoli, Maxim Bazhenov
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Neurobiology of Disease
Subjects:
KCC2 co-transporter
4-aminopyridine
Epileptic seizures
Ion concentration dynamics
Network models
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117302371

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http://www.sciencedirect.com/science/article/pii/S0969996117302371

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