A novel mutation in CFAP47 causes male infertility due to multiple morphological abnormalities of the sperm flagella

A novel mutation in CFAP47 causes male infertility due to multiple morphological abnormalities of the sperm flagella

IntroductionA previous study suggested that loss of CFAP47 function is involved in multiple morphological abnormalities of the sperm flagella (MMAF) in humans and mice. However, the comprehensive role of CFAP47 in spermatogenesis is largely unknown.MethodsWhole-exome sequencing (WES) was conducted t...

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Bibliographic Details
Main Authors: Mohan Liu, Siyu Dai, Jiying Zhang, Yihong Yang, Ying Shen, Hongqian Liu, Yanting Yang, Chuan Jiang, Erpo Tian
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Endocrinology
Subjects:
asthenoteratozoospermia
MMAF
CFAP47
hemizygous mutation
WES
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1155639/full

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https://www.frontiersin.org/articles/10.3389/fendo.2023.1155639/full

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