A Small Natural Molecule S3 Protects Retinal Ganglion Cells and Promotes Parkin-Mediated Mitophagy against Excitotoxicity

A Small Natural Molecule S3 Protects Retinal Ganglion Cells and Promotes Parkin-Mediated Mitophagy against Excitotoxicity

Glutamate excitotoxicity may contribute to retinal ganglion cell (RGC) degeneration in glaucoma and other optic neuropathies, leading to irreversible blindness. Growing evidence has linked impaired mitochondrial quality control with RGCs degeneration, while parkin, an E3 ubiquitin ligase, has proved...

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Bibliographic Details
Main Authors: Dongli Zhuang, Rong Zhang, Haiyang Liu, Yi Dai
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Molecules
Subjects:
excitotoxicity
retinal ganglion cells
15-oxospiramilactone
mitophagy
parkin
Online Access:https://www.mdpi.com/1420-3049/27/15/4957

Internet

https://www.mdpi.com/1420-3049/27/15/4957

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