Aggregation of alpha-synuclein in enteric neurons does not impact function in vitro

Abstract Recent evidence implicates a gut-first pathogenesis in the enteric nervous system (ENS) within a portion of PD patients, yet in vitro investigations have primarily focused on the central nervous system. Here, the preformed fibril (PFF) PD model is applied with co-administered groups of buty...

Full description

Bibliographic Details
Main Authors: Adam J. Bindas, Kyla N. Nichols, Nicole J. Roth, Ryan Brady, Abigail N. Koppes, Ryan A. Koppes
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-26543-x