Analysis of asymptomatic Drosophila models for ALS and SMA reveals convergent impact on functional protein complexes linked to neuro-muscular degeneration

Analysis of asymptomatic Drosophila models for ALS and SMA reveals convergent impact on functional protein complexes linked to neuro-muscular degeneration

Abstract Background Spinal Muscular Atrophy (SMA) and Amyotrophic Lateral Sclerosis (ALS) share phenotypic and molecular commonalities, including the fact that they can be caused by mutations in ubiquitous proteins involved in RNA metabolism, namely SMN, TDP-43 and FUS. Although this suggests the ex...

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Bibliographic Details
Main Authors: Marina L. Garcia-Vaquero, Marjorie Heim, Barbara Flix, Marcelo Pereira, Lucile Palin, Tânia M. Marques, Francisco R. Pinto, Javier de Las Rivas, Aaron Voigt, Florence Besse, Margarida Gama-Carvalho
Format: Article
Language:English
Published: BMC 2023-09-01
Series:BMC Genomics
Subjects:
ALS
SMA
Motor neuron
Drosophila
SMN
TDP-43
Online Access:https://doi.org/10.1186/s12864-023-09562-4

Internet

https://doi.org/10.1186/s12864-023-09562-4

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