Tau reduction attenuates autism-like features in Fmr1 knockout mice

Tau reduction attenuates autism-like features in Fmr1 knockout mice

Abstract Background Fragile X syndrome (FXS) is a leading cause of autism spectrum disorder (ASD) and resulted from a loss of the FMR1-encoded fragile X messenger ribonucleoprotein 1 (FMRP) protein due to large CGG repeat expansions in the promoter region of the FMR1 gene. The microtubule-associated...

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Bibliographic Details
Main Authors: Shanshan Zhao, Xiangyu Jiang, Linkun Han, Yiru Jiang, Yong Wang, Jian Meng, Xiang Zhu, Xian Zhang, Hong Luo, Yun-wu Zhang
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Molecular Autism
Subjects:
Antisense oligonucleotide
Autism spectrum disorder
FMR1
Fragile X syndrome
P38/MAPK signaling
Tau
Online Access:https://doi.org/10.1186/s13229-023-00574-1

Internet

https://doi.org/10.1186/s13229-023-00574-1

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