Contrasting DNA-binding behaviour by ISL1 and LHX3 underpins differential gene targeting in neuronal cell specification

Contrasting DNA-binding behaviour by ISL1 and LHX3 underpins differential gene targeting in neuronal cell specification

The roles of ISL1 and LHX3 in the development of spinal motor neurons have been well established. Whereas LHX3 triggers differentiation into interneurons, the additional expression of ISL1 in developing neuronal cells is sufficient to redirect their developmental trajectory towards spinal motor neur...

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Bibliographic Details
Main Authors: Ngaio C. Smith, Lorna E. Wilkinson-White, Ann H.Y. Kwan, Jill Trewhella, Jacqueline M. Matthews
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Journal of Structural Biology: X
Subjects:
Homeodomain-DNA interaction
DNA-binding specificity
Transcriptional complex
SAXS
LIM-homeodomain transcription factors
Online Access:http://www.sciencedirect.com/science/article/pii/S2590152420300295

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http://www.sciencedirect.com/science/article/pii/S2590152420300295

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