Tenuazonic acid: a promising antitubercular principle from Alternaria alternate
Bioactivity guided isolation of dichloromethane extract of <em>Alternaria alternata</em> identified tenuazonic acid (1) as potentially active against <em>Mycobacterium tuberculosis</em> H37Rv, MIC at 250 μg/mL concentration. This active metabolite 1, was also evaluated for os...
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-10-01
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| Series: | Microbiology Research |
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| Online Access: | http://www.pagepress.org/journals/index.php/mr/article/view/2886 |
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| author | Visalakchi Sonaimuthu Swati Parihar Jay Prakash Thakur Suaib Luqman Dharmendra Saikia Chandan S. Chinotiya Muthumary Jhonpaul Arvind Singh Negi |
| author_facet | Visalakchi Sonaimuthu Swati Parihar Jay Prakash Thakur Suaib Luqman Dharmendra Saikia Chandan S. Chinotiya Muthumary Jhonpaul Arvind Singh Negi |
| author_sort | Visalakchi Sonaimuthu |
| collection | DOAJ |
| description | Bioactivity guided isolation of dichloromethane extract of <em>Alternaria alternata</em> identified tenuazonic acid (1) as potentially active against <em>Mycobacterium tuberculosis</em> H37Rv, MIC at 250 μg/mL concentration. This active metabolite 1, was also evaluated for osmotic hemolysis using the erythrocyte as a model system. It was observed that this fungal metabolite showing antitubercular activity exhibited concentration dependent toxicity to human erythrocytes. |
| first_indexed | 2024-04-11T16:35:08Z |
| format | Article |
| id | doaj.art-c0efc295b8e544b891072c7fc65121e7 |
| institution | Directory Open Access Journal |
| issn | 2036-7473 2036-7481 |
| language | English |
| last_indexed | 2024-04-11T16:35:08Z |
| publishDate | 2011-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microbiology Research |
| spelling | doaj.art-c0efc295b8e544b891072c7fc65121e72022-12-22T04:13:51ZengMDPI AGMicrobiology Research2036-74732036-74812011-10-0122e17e1710.4081/mr.2011.e171691Tenuazonic acid: a promising antitubercular principle from Alternaria alternateVisalakchi Sonaimuthu0Swati Parihar1Jay Prakash Thakur2Suaib Luqman3Dharmendra Saikia4Chandan S. Chinotiya5Muthumary Jhonpaul6Arvind Singh Negi7Centre for Advanced Studies in Botany, University of Madras, Guindy Campus, Chennai, Tamil NaduCentral Institute of Medicinal and Aromatic Plants (CIMAP-CSIR), Kukrail Picnic Spot Road, LucknowCentral Institute of Medicinal and Aromatic Plants (CIMAP-CSIR), Kukrail Picnic Spot Road, LucknowCentral Institute of Medicinal and Aromatic Plants (CIMAP-CSIR), Kukrail Picnic Spot Road, LucknowCentral Institute of Medicinal and Aromatic Plants (CIMAP-CSIR), Kukrail Picnic Spot Road, LucknowCentral Institute of Medicinal and Aromatic Plants (CIMAP-CSIR), Kukrail Picnic Spot Road, LucknowCentre for Advanced Studies in Botany, University of Madras, Guindy Campus, Chennai, Tamil NaduCentral Institute of Medicinal and Aromatic Plants (CIMAP-CSIR), Kukrail Picnic Spot Road, LucknowBioactivity guided isolation of dichloromethane extract of <em>Alternaria alternata</em> identified tenuazonic acid (1) as potentially active against <em>Mycobacterium tuberculosis</em> H37Rv, MIC at 250 μg/mL concentration. This active metabolite 1, was also evaluated for osmotic hemolysis using the erythrocyte as a model system. It was observed that this fungal metabolite showing antitubercular activity exhibited concentration dependent toxicity to human erythrocytes.http://www.pagepress.org/journals/index.php/mr/article/view/2886Alternaria alternata, tenuazonic acid, Mycobacterium tuberculosis, antitubercular, toxicity, erythrocyte fragility |
| spellingShingle | Visalakchi Sonaimuthu Swati Parihar Jay Prakash Thakur Suaib Luqman Dharmendra Saikia Chandan S. Chinotiya Muthumary Jhonpaul Arvind Singh Negi Tenuazonic acid: a promising antitubercular principle from Alternaria alternate Microbiology Research Alternaria alternata, tenuazonic acid, Mycobacterium tuberculosis, antitubercular, toxicity, erythrocyte fragility |
| title | Tenuazonic acid: a promising antitubercular principle from Alternaria alternate |
| title_full | Tenuazonic acid: a promising antitubercular principle from Alternaria alternate |
| title_fullStr | Tenuazonic acid: a promising antitubercular principle from Alternaria alternate |
| title_full_unstemmed | Tenuazonic acid: a promising antitubercular principle from Alternaria alternate |
| title_short | Tenuazonic acid: a promising antitubercular principle from Alternaria alternate |
| title_sort | tenuazonic acid a promising antitubercular principle from alternaria alternate |
| topic | Alternaria alternata, tenuazonic acid, Mycobacterium tuberculosis, antitubercular, toxicity, erythrocyte fragility |
| url | http://www.pagepress.org/journals/index.php/mr/article/view/2886 |
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