NGS Analysis Confirms Common <i>TP53</i> and <i>RB1</i> Mutations, and Suggests <i>MYC</i> Amplification in Ocular Adnexal Sebaceous Carcinomas

NGS Analysis Confirms Common <i>TP53</i> and <i>RB1</i> Mutations, and Suggests <i>MYC</i> Amplification in Ocular Adnexal Sebaceous Carcinomas

Ocular adnexal (OA) sebaceous carcinomas generally demonstrate more aggressive clinical and histopathological phenotypes than extraocular cases, but the molecular drivers implicated in their oncogenesis remain poorly defined. A retrospective review of surgical and ocular pathology archives identifie...

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Bibliographic Details
Main Authors: Cornelia Peterson, Robert Moore, Jessica L. Hicks, Laura A. Morsberger, Angelo M. De Marzo, Ying Zou, Charles G. Eberhart, Ashley A. Campbell
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
sebaceous carcinoma
ocular adnexal tumor
next-generation sequencing
MYC
Online Access:https://www.mdpi.com/1422-0067/22/16/8454

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https://www.mdpi.com/1422-0067/22/16/8454

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