Functional Characterization of Spinocerebellar Ataxia Associated Dynorphin A Mutant Peptides

Functional Characterization of Spinocerebellar Ataxia Associated Dynorphin A Mutant Peptides

Mutations in the prodynorphin gene (<i>PDYN</i>) are associated with the development of spinocerebellar ataxia type 23 (SCA23). Pathogenic missense mutations are localized predominantly in the <i>PDYN</i> region coding for the dynorphin A (DynA) neuropeptide and lead to persi...

Full description

Bibliographic Details
Main Authors: Andreas Lieb, Germana Thaler, Barbara Fogli, Olga Trovato, Mitja Amon Posch, Teresa Kaserer, Luca Zangrandi
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Biomedicines
Subjects:
dynorphin
kappa opioid receptor
spinocerebellar ataxia
β-arrestin
G-protein
functional selectivity
Online Access:https://www.mdpi.com/2227-9059/9/12/1882

Internet

https://www.mdpi.com/2227-9059/9/12/1882

Similar Items