CHIP/STUB1 Ubiquitin Ligase Functions as a Negative Regulator of ErbB2 by Promoting Its Early Post-Biosynthesis Degradation

CHIP/STUB1 Ubiquitin Ligase Functions as a Negative Regulator of ErbB2 by Promoting Its Early Post-Biosynthesis Degradation

Overexpression of the epidermal growth factor receptor (EGFR) family member ErbB2 (HER2) drives oncogenesis in up to 25% of invasive breast cancers. ErbB2 expression at the cell surface is required for oncogenesis but mechanisms that ensure the optimal cell surface display of overexpressed ErbB2 fol...

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Bibliographic Details
Main Authors: Haitao Luan, Tameka A. Bailey, Robert J. Clubb, Bhopal C. Mohapatra, Aaqib M. Bhat, Sukanya Chakraborty, Namista Islam, Insha Mushtaq, Matthew D. Storck, Srikumar M. Raja, Vimla Band, Hamid Band
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
CHIP/STUB1
ubiquitin
ubiquitin ligase
E3
breast cancer
ErbB2
Online Access:https://www.mdpi.com/2072-6694/13/16/3936

Internet

https://www.mdpi.com/2072-6694/13/16/3936

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