Tissue-engineered collagenous fibrous cap models to systematically elucidate atherosclerotic plaque rupture

Abstract A significant amount of vascular thrombotic events are associated with rupture of the fibrous cap that overlie atherosclerotic plaques. Cap rupture is however difficult to predict due to the heterogenous composition of the plaque, unknown material properties, and the stochastic nature of th...

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Bibliographic Details
Main Authors: T. B. Wissing, K. Van der Heiden, S. M. Serra, A. I. P. M. Smits, C. V. C. Bouten, F. J. H. Gijsen
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-08425-4