1,2-Hydrogenation and Transhydrogenation Catalyzed by 3-Ketosteroid Δ<sup>1</sup>-Dehydrogenase from <i>Sterolibacterium denitrificans</i>—Kinetics, Isotope Labelling and QM:MM Modelling Studies

1,2-Hydrogenation and Transhydrogenation Catalyzed by 3-Ketosteroid Δ<sup>1</sup>-Dehydrogenase from <i>Sterolibacterium denitrificans</i>—Kinetics, Isotope Labelling and QM:MM Modelling Studies

Bacteria and fungi that are able to metabolize steroids express 3-ketosteroid-Δ<sup>1</sup>-dehydrogenases (KstDs). KstDs such as AcmB form <i>Sterolibacterium denitrificans</i> Chol-1 catalyze the enantioselective 1α,2β-dehydrogenation of steroids to their desaturated analog...

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Bibliographic Details
Main Authors: Agnieszka M. Wojtkiewicz, Michał Glanowski, Piotr Waligórski, Tomasz Janeczko, Maciej Szaleniec
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
3-ketosteroid dehydrogenase
KstD
flavin enzyme
transhydrogenation
hydrogenation
Online Access:https://www.mdpi.com/1422-0067/23/23/14660

Internet

https://www.mdpi.com/1422-0067/23/23/14660

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