Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance.

Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance.

Multidrug-resistant Plasmodium falciparum parasites have emerged in Cambodia and neighboring countries in Southeast Asia, compromising the efficacy of first-line antimalarial combinations. Dihydroartemisinin + piperaquine (PPQ) treatment failure rates have risen to as high as 50% in some areas in th...

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Bibliographic Details
Main Authors: Jennifer L Small-Saunders, Laura M Hagenah, Kathryn J Wicht, Satish K Dhingra, Ioanna Deni, Jonathan Kim, Jeremie Vendome, Eva Gil-Iturbe, Paul D Roepe, Monica Mehta, Filippo Mancia, Matthias Quick, Margaret J Eppstein, David A Fidock
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010278

Internet

https://doi.org/10.1371/journal.ppat.1010278

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